Wednesday, 23 July 2014

Human proteome more complex than previously thought

Human proteome is more complex than was previously thought.

More than 250 splicing variants of a highly conserved human gene family have been identified. Details were published in Science in July this year [1]. See also here.

We are definitely going to see progressively more 'complex-than-previously-thought' discoveries, which is perfectly in line with a general trend in biology predicted by ID. This trend has always been there, but perhaps it is most clearly seen over the past few decades, starting with the discovery of DNA in 1953. Further investigations progressively revealed an immense functional complexity of life. The once prevailing junk DNA evolutionary hypothesis attempting to explain a relatively low percentage of protein coding DNA in all DNA, has been essentially debunked. Contrary to evolutionary expectations, most regions of the DNA molecule are used to regulate the process of gene expression. And now it seems that gene splicing adds an extra level of complexity to the picture.


  1. W.S. Lo et al., “Human tRNA synthetase catalytic nulls with diverse functions,” Science, doi:10.1126/science.1252943, 2014.

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